Solution of mercurous oxycyanid and dianisyl-monophenetidyl-guanidinchlorhydrate.



- less painful.

I UNITED STATES PATENT UFFICE. JACOB enone mason, OF flflflp ISCHE FABRIK VONIIEYDEN, AKTIENGESELLSCHAFT, OF RADEBEUL, NEAR DRESDEN, GERMANY.

SOLUTION 0F MERCUROUS OXYCYANID AND DIANISYL-MONOPHENET!DYL-GUANIDINCHLORHYDRATE.

Specification of Letters Patent. Patented March 12, 1907.

' Application filed August 10, 1906- Serial No. 329.957.

hydrochloric or nitric acid-are added to one hundred grams of aconcentrated solution of mercurous oxycyanid, this solution remains clear and gives noprecipitate when mixed with a one-per-cent. aqueous solution of dianis'yl monophenetidyl guanidinchlorhydrate.

For antisyphilitic subcutaneous injections I thus prepare, for instance, a mixture of three parts of a one'and two-thirds per cent. solution of mercurous oxycyanid with two parts of a oneer-cent. solution of dyanisylmonophenety 'l guanidicinchlorhydrate. This injection causes no pain.

What I claim is An aqueous solution of 0.5 up to 1.5 per cent. of mercurous oxycyanid and 0.3 up to 1.0 dinchlorhydrate containing such a small quantity of an acid as is suflicient to secure a clear state of the solution, substantially as described.

In testimony that I claim the foregoing as my invention 1 have signed my name, in presence of two witnesses, this 27th day of July.

To all whom it may concern/.-

Be it known that I, JACOB GEORG Hrnson, a subject of-the King of Prussia, and a resident of Linden'meg 38, at Halberstadt, King l dom of Prussia, German Empire, have invented a new and useful Improvement in a Clear Solution of Merourous Oxycyanid and Dianisyl Monophenetidyl Guanidinchlorhydrate, of which the following is a specification.

In therapy subcutaneous injections of concentrated about one per cent.-'aqueous solutions of mercurous oxycyanid (=hydrargyrum oxycyanatum, HgO.Hg (CN) are employed as a cure for syphilis. These injections are, like all other of that kind, more or I have tried to remove the painfulness by an addition of dianisyl-monophenetidylguanidinchlorhydrate, an anes-- thetic.

A solution of mercurous oxycyanid can be mixed with a solution of dianisyl-monophenetidyl-guanidinchlorhydrate if both solutions are very diluted-ones-i. e., 121000 of more. In a one-per-cent. solution of mercurous oxycyanid, hofivlevlelr, dianisyl-mono- 1906.

phenetidylanidinc or ydrate forms at once a precgjiitate, so that the mixture. can- JACOB GEORG HIRSCH" not be used. l Witnesses:

'EnNsT THIEMs,

I have discovered the following fact: If

ARTUR Hmson.

about five drops of an acidfor example,

miLBERsTAD T, GERMANY, ASSIGNOR TO CHEM-- per cent. dianisyl-monophenetidyl-guam- 

